KPV
KPV - Anti-Inflammatory Tripeptide (α-MSH Fragment)
KPV (Lys-Pro-Val) is a C-terminal tripeptide fragment derived from alpha-melanocyte stimulating hormone (α-MSH). Despite being only three amino acids in length, KPV retains the potent anti-inflammatory activity of its parent molecule while being small enough to resist enzymatic degradation and penetrate tissues efficiently. This makes KPV one of the most targeted anti-inflammatory peptides available for research.
Mechanism of Action
KPV exerts anti-inflammatory effects through multiple mechanisms: it inhibits NF-κB nuclear translocation by preventing IκB-α phosphorylation, reduces pro-inflammatory cytokine production (IL-1β, IL-6, TNF-α), and modulates inflammatory cell migration. KPV also interacts with melanocortin receptors, though its anti-inflammatory activity appears partially independent of classical MC receptor binding. Research has demonstrated its ability to cross intestinal epithelial barriers, making it valuable for mucosal inflammation studies.
Research Applications
- NF-κB pathway inhibition and inflammatory signaling
- Mucosal healing and intestinal barrier function
- Cytokine modulation (IL-1β, IL-6, TNF-α reduction)
- Inflammatory bowel disease pathway research
- Inflammatory pathway research
- Comparative studies with full-length α-MSH
| Product Name | KPV |
|---|---|
| Quantity | 10mg per vial |
| Purity | ≥99% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | Refrigerate after reconstitution. Store lyophilized at -20°C. |
| Testing | USA lab tested. COA available on request. |
| Receptor Targets | |
| Mechanism | |
| SKU | MBR-KPV |
| Intended Use | Research purposes only. Not for human use. |
Technical Specifications
| Product Name | — |
| Dosage / SKU | — |
| Form | Lyophilized Powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C long-term; 4°C short-term |
| Reconstitution | Bacteriostatic Water or Sterile Water |
| Shelf Life | 24 months from manufacture date |
| Origin | US-Based, Third-Party Verified |