MOTS-C
MOTS-C - Mitochondrial-Derived Peptide
MOTS-C (Mitochondrial Open Reading Frame of the Twelve S rRNA type-C) is a 16-amino acid peptide encoded within the mitochondrial genome - one of only a few known mitochondrial-derived peptides (MDPs). Its discovery has opened new frontiers in understanding how mitochondrial DNA communicates with the nuclear genome to regulate systemic metabolism.
Mechanism of Action
MOTS-C activates the AMPK pathway (5′ AMP-activated protein kinase), a master regulator of cellular energy homeostasis. Through AMPK activation, MOTS-C enhances glucose uptake, promotes fatty acid oxidation, and improves mitochondrial respiration. Research has shown that MOTS-C translocates to the nucleus under metabolic stress, where it directly regulates gene expression related to antioxidant response elements (ARE) through interaction with the NRF2 pathway.
Research Applications
- AMPK pathway activation and metabolic regulation
- Exercise mimetic and endurance physiology studies
- Insulin sensitivity and glucose metabolism research
- Mitochondrial-nuclear communication (retrograde signaling)
- Aging biomarker and longevity pathway investigations
- Metabolic stress response mechanisms
| Product Name | MOTS-C |
|---|---|
| Quantity | 10-40mg per vial (select option) |
| Purity | ≥99% (HPLC verified) |
| Form | Lyophilized powder |
| Storage | Refrigerate after reconstitution. Store lyophilized at -20°C. |
| Testing | USA lab tested. COA available on request. |
| Receptor Targets | |
| Mechanism | |
| SKU | MBR-MOTSC |
| Intended Use | Research purposes only. Not for human use. |
Technical Specifications
| Product Name | — |
| Dosage / SKU | — |
| Form | Lyophilized Powder |
| Purity | ≥99% (HPLC verified) |
| Storage | -20°C long-term; 4°C short-term |
| Reconstitution | Bacteriostatic Water or Sterile Water |
| Shelf Life | 24 months from manufacture date |
| Origin | US-Based, Third-Party Verified |